The Rat Fan Club
A Possible New Cancer Treatment
“The Rat Lady” Ducommun
This article first appeared in the Rat-a-tat Chat, the newsletter of the non-profit organization Rat
Assistance & Teaching Society.
To join RATS and subscribe to the newsletter go to www.petrats.org
Nitroxoline is an antibiotic that has been used to treat
urinary infections in Europe for about fifty years. It works by blocking the
ability of bacteria to replicate. In 2010 researchers at Johns Hopkins School
of Medicine discovered that it also can help to slow the growth of tumors by
blocking the formation of new blood vessels that the tumors need to grow.
Giving nitroxoline to mice with either mammary cancer
or bladder cancer found that the tumors shrank by 50 to 60%. The dose that was
given to the mice was 13.6 mg/lb once a day.
2011, researchers in Slovenia also found that nitroxoline
might also help prevent cancers from metastasizing because it inhibits an
enzyme that breaks down the outer membrane of tumors, allowing the cells to
this antibiotic is not available in the U.S., but in doing a search for information about nitroxoline online, I found it listed for sale on
Amazon.com from a vendor that sells items from Russia! So, if your rat has cancer, you might consider
trying this treatment.
Antibiotic Slows Growth of
Bladder, Breast Cancer Cells, JAMA,
2004 Feb 18;291(7):827-35.
J Natl Cancer
Inst. 2010 December 15; 102(24): 1855–1873.
For breast cancer, mice were
injected with 60-mg/kg nitroxoline in vehicle, intraperitoneally, every other day for 30 days.
For bladder cancer mice were
given nitroxoline in vehicle (30 mg/kg/day, n = 6) by
oral administration daily for 2 weeks.
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