The Rat Fan Club


Possible New Cancer Treatments

by Debbie “The Rat Lady” Ducommun

8/12/14

These articles first appeared in the Rat-a-tat Chat, the newsletter of the non-profit organization Rat Assistance & Teaching Society.

To join RATS and subscribe to the newsletter go to www.petrats.org

 

Tamoxifen for Other Cancers

            Whenever rat owners have asked me if tamoxifen can be used to treat tumors other than mammary cancer, I have always said no, because I thought it only worked for estrogen sensitive tumors. However, I recently got an email from rat owner Paul Gregor who is a scientist interested in how different drugs work. His rat has grown some tumors, so he was reading the info I have about tamoxifen on my website. He told me that there is scientific evidence that tamoxifen can help slow the growth of cancers other than mammary tumors. It appears that tamoxifen not only blocks estrogen receptor sites in tumors, but it also helps prevent the growth of new blood vessels, which a tumor must do to grow.

            One study found that tamoxifen helped slow the growth of squamous cell carcinoma cells in a culture. This was an in vitro experiment, using cell cultures and not tumors growing in animals, which means that no animals were harmed for this experiment! The cancer cells used in this study were from squamous cell carcinoma tumors on the head and neck of humans, which are apparently very difficult to treat. One of the most common types of cancer in rats is squamous cell carcinoma on the head and face! Although this study showed that treatment of the cancer cells was most successful when tamoxifen was used together with a chemotherapy drug called cisplatin, just the tamoxifen by itself did help slow the grow of the cancer cells. (Cisplatin must be given intravenously, and so is not practical for rat treatment.)

            Although in vitro studies are wonderful because they do not use animals, it is also good to know that tamoxifen appeared to slow the growth of malignant fibrosarcoma tumors implanted in rats, since fibrosarcoma is also a fairly common type of cancer in rats. This study found that tamoxifen helped to slow the growth of blood vessels in the tumors, which would presumably slow the growth of tumors. The rats were euthanized only ten days after the tumor cells were implanted in their legs, so this study did not look at long-term effects of the treatment.

            So, if your rat has cancer, any kind of cancer, it looks like it might be worth it try treatment with tamoxifen.

 

References:

Tamoxifen Inhibits Angiogenesis in Estrogen Receptor-negative Animal Models. Clin Cancer Res., Blackwell, K.L. et al. November 2000 6; 4359.

http://clincancerres.aacrjournals.org/content/6/11/4359.abstract

 

Tamoxifen inhibits the growth of head and neck cancer cells and sensitizes these cells to cisplatin induced-apoptosis: role of TGF-β1. Tavassol, M., et al. Carcinogenesis October 1, 2002 23:1569-1576.

http://carcin.oxfordjournals.org/content/23/10/1569.full.pdf+html

 

Possible New Cancer Treatment

            Nitroxoline is an antibiotic that has been used to treat urinary infections in Europe for about fifty years. It works by blocking the ability of bacteria to replicate. In 2010 researchers at Johns Hopkins School of Medicine discovered that it also can help to slow the growth of tumors by blocking the formation of new blood vessels that the tumors need to grow. Giving nitroxoline to mice with either mammary cancer or bladder cancer found that the tumors shrank by 50 to 60%. The dose that was given to the mice was 13.6 mg/lb once a day.

            In 2011, researchers in Slovenia also found that nitroxoline might also help prevent cancers from metastasizing because it inhibits an enzyme that breaks down the outer membrane of tumors, allowing the cells to float free.

            Apparently, this antibiotic is not available in the U.S., but in doing a search for information about nitroxoline online, I found it listed for sale on Amazon.com from a vendor that sells items from Russia! So, if your rat has cancer, you might consider trying this treatment.

 

References:

Antibiotic Slows Growth of Bladder, Breast Cancer Cells, JAMA, 2004 Feb 18;291(7):827-35.

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001967/

J Natl Cancer Inst. 2010 December 15; 102(24): 1855–1873.

For breast cancer, mice were injected with 60-mg/kg nitroxoline in vehicle, intraperitoneally, every other day for 30 days.

For bladder cancer mice were given nitroxoline in vehicle (30 mg/kg/day, n = 6) by oral administration daily for 2 weeks.

 


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